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Clinical Trial Data Show Reduced Drug Response To understand how GLP-1 resistance affects treatment outcomes, the team analyzed data from several clinical trials involving people with diabetes

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It works on GLP-1 receptors in the pancreas, brain, and gut

Participants were required to have obesity at baseline, defined as BMI 30, or a diagnosis of obesity using International Classification of Diseases, Ninth and Tenth Revision (ICD-9 [ and ICD-10 [ registered in the VID medical record in the 365 days before the index date, and to be taking metformin on the index date

This combination addresses the potential for B12 deficiency that can develop with long-term GLP-1 agonist use because reduced food intake means reduced vitamin absorption